Glutathione is a tripeptide composed of the amino acids glutamine, cysteine, and glycine (L-γ-glutamyl-L-cysteinyl-glycine). As the most abundant endogenous antioxidant, glutathione plays critical roles in cellular defense against oxidative stress, detoxification of xenobiotics, immune function, and maintaining cellular redox homeostasis. Glutathione exists in reduced (GSH) and oxidized (GSSG) states, with the ratio between these forms serving as an important indicator of cellular oxidative stress. It acts as a cofactor for multiple enzymatic reactions and is essential for the regeneration of other antioxidants like vitamins C and E.
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